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A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus.

By Guo-Jen Huang, Adrian L Smith, Daniel H D Gray, Cormac Cosgrove, Benjamin H Singer, Andrew Edwards, Stuart Sims, Jack M Parent, Alyssa Johnsen, Richard Mott, Diane Mathis, Paul Klenerman, Christophe Benoist and Jonathan Flint

Abstract

Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear. Measuring cellular proliferation in the hippocampus of 719 outbred heterogeneous stock mice revealed a highly significant correlation with the proportions of CD8+ versus CD4+ T lymphocyte subsets. This correlation reflected shared genetic loci, with the exception of the H-2Ea locus that had a dominant influence on T cell subsets but no impact on neurogenesis. Analysis of knockouts and repopulation of TCRα-deficient mice by subsets of T cells confirmed the influence of T cells on adult neurogenesis, indicating that CD4+ T cells or subpopulations thereof mediate the effect. Our results reveal an organismal impact, broader than hitherto suspected, of the natural genetic variation that controls T cell development and homeostasis

Topics: Biology (General), QH301-705.5
Publisher: Public Library of Science (PLoS)
Year: 2010
DOI identifier: 10.1371/journal.pbio.1000561
OAI identifier: oai:doaj.org/article:7448670e6c53468698a30ec5ccd1c935
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