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ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS

By I. V. Nekrasova, S. V. Shirshev and I. Yu. Danchenko

Abstract

<p>We studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,<br />upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, as<br />well as the production of relevant cytokines by the cells of patients with multiple sclerosis (MS), as compared<br />with healthy donors. It was found that the levels of CD4+FoxP3+CTLA-4+ (Treg) lymphocytes in MS patients<br />were initially lower than those of healthy donors. Percentages of CD4+RORγt+IL-17A+ (Th17) lymphocytes<br />did not significantly differ from those in healthy donors, still showing a tendency for increase. Baseline levels<br />of IL-17 and IL-6 in cell culture supernates of MS patients were higher than in healthy donors, along with<br />reduced contents of the anti-inflammatory IL-10 cytokine. Percentage of Tregs was increased under the<br />influence of estriol, whereas Th17 proportion was diminished. These hormonal effects upon lymphocytes<br />were reproducible both for healthy donors, and MS patients. Moreover, estriol stimulated IL-10 production<br />and inhibited secretion of IL-6 and IL-17. Therefore, a sufficient release of MS symptoms observed during<br />pregnancy may be explained by influence of estriol, thus extending opportunities for rational use of this steroid<br />hormone in MS treatment</p

Topics: рассеянный склероз, эстриол, Т-регуляторные лимфоциты, Th17-продуцирующие лимфоциты, цитокины, Immunologic diseases. Allergy, RC581-607
Publisher: SPb RAACI
Year: 2014
OAI identifier: oai:doaj.org/article:f3f663ba9e7c488fb106971d8a5966d6
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