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POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES

By E. P. Kiseleva, O. V. Tsyganova, K. I. Mikhailopulo, O. V. Sviridov, Y. E. Demidchic, A. V. Izhik, Y. A. Knirel and G. I. Novik

Abstract

It was revealed, that, in blood samples of the patients with autoimmune thyroid diseases, serum antibodies against cell-free fraction of Bifidobacterium bifidum 791 and Lactobacillus plantarum B-01 were detected, respectively, in 71 and 63% of cases, that being two-fold higher than appropriate frequencies in healthy blood donors. An evidence was obtained that presence of some components specifically reacting with autoantibodies against thyroid peroxidase and thyroglobulin on the surface of the microorganisms cells and competing for binding of these immunoglobulins with thyroid antigens. One may also suggest a presence of bacterial components, interacting with thyroid peroxidase. The data obtained let us suggest that probiotic microorganisms of Bifidobacterium and Lactobacillus genus could take part in pathogenesis of autoimmune thyroid diseases, by means of molecular mimicry mechanisms

Topics: бифидобактерии, лактобактерии, тироглобулины, антитела, молекулярная мимикрия, Immunologic diseases. Allergy, RC581-607
Publisher: SPb RAACI
Year: 2010
OAI identifier: oai:doaj.org/article:8b25441bd0194e57af2de5269ba25700
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