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GALECTIN-1 AND ITS ROLE IN DEVELOPMENT OF INNATE AND ADAPTIVE IMMUNITY

By V. D. Yakushina, O. A. Vasilyeva, N. V. Ryazantseva, V. V. Novitsky, O. E. Savelyeva, T. S. Prokhorenko, E. G. Starikova and A. P. Zima

Abstract

<strong>Abstract.</strong> Galectins comprise a family of β-galactoside-binding animal proteins, which are defined by<br />common homologies of their carbohydrate-recognizing domaine (affinity for poly-N-acetyllactosamine). These lectins bind to cell surface glycans and extracellular matrix, thus influencing various cellular events, including cell cycle, adhesion, migration, proliferation and apoptosis. Moreover, galectins are able to exert intracellular effects, and participate, e.g., in signal transduction, by interacting with other nuclear and cytoplasmic proteins. Galectin-1 is considered to play a special role in functional regulation of immune cell activity. Thus protein is a factor of immunocompetent cell cooperation, thus being able to modulate immune reactions. In this respect, galectin-1 is considered as a potential agent or a target for new methods aimed to correct pathological processes associated with imbalance of immune system. This article provides an overview of works devoted to a possible role of galectin-1 in development of typical features of innate and adaptive immunity

Topics: галектин-1, иммунитет, апоптоз, дифференцировка Тh-лимфоцитов, Immunologic diseases. Allergy, RC581-607
Publisher: SPb RAACI
Year: 2012
OAI identifier: oai:doaj.org/article:8ec4a611aaa14c8a8f3273c8bd9d3a03
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