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ROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION

By E. G. Lobanova

Abstract

<strong>Abstract. </strong>Expression of endocannabinoid receptors (СВ1, СВ2) in immunocompetent cells was studied under the conditions of <em>in vivo </em>stimulation of immune system. Intracorporeal blood irradiation and enrichment of peripheral blood by ozone/oxygen mixture were used to stimulate immune system. It was revealed that normal amounts of mononuclear leukocytes (MLs) expressing a differentiating surface antigen for СВ2 receptor exceeded 90%. We have not detected MLs with a differentiating antigen to СВ1 receptor. <em>In vivo </em>stimulation of immune system caused a suppressed endocannabinoid СВ2 receptor expression on ML surface. The data provide a direct proof for involvement of endocannabinoid system in immune response regulation

Topics: мононуклеарные лейкоциты, эндоканнабиноидные рецепторы СВ1 и СВ2, иммунный ответ, Immunologic diseases. Allergy, RC581-607
Publisher: SPb RAACI
Year: 2012
OAI identifier: oai:doaj.org/article:925e57fa3a644bfca7196845169cce57
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