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ROLE OF ENDOTHELIAL CELLS IN REGULATION OF APOPTOSIS OF HIV-1 INFECTED CD4+ LYMPHOCYTES

By S. V. Boichuk, I. G. Mustafin and M. V. Makarova

Abstract

<p><strong><span><span>Abstract. </span></span></strong><span style="font-family: PetersburgC; font-size: small;"><span style="font-family: PetersburgC; font-size: small;">Vascular endothelial cells (VECs) are able to induce HIV1 replication in СD4</span></span><span style="font-family: PetersburgC; font-size: xx-small;"><span style="font-family: PetersburgC; font-size: xx-small;">+ </span></span><span style="font-family: PetersburgC; font-size: small;"><span style="font-family: PetersburgC; font-size: small;">Tcells, thus deter</span></span>mining their resistance for apoptosis. The revealed facts are specific to EC/Tcell culture and are stipulated by the cellcell interactions between the VECs and HIV1 producing cells, thus being a consequence of activation of ‘productively infected’ T cells.</p

Topics: эндотелиальные клетки, лимфоциты, ВИЧ-1, репликация, апоптоз, Immunologic diseases. Allergy, RC581-607
Publisher: SPb RAACI
Year: 2006
OAI identifier: oai:doaj.org/article:57e58a4672a5461e8e29a2f9b2058e8b
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