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OPPORTUNITIES OF FLOW CYTOMETRY IN DIAGNOSTICS OF INFECTIOUS DISEASES. Part 2

By S. V. Khaidukov and A. V. Zurochka

Abstract

<p><strong>Abstract.</strong> Flow cytometry allows estimating quantitative and qualitative structure of populations and subpopulations of immune system cells by using various methodical approaches and a wide spectrum of reagents. For diagnostics the Acquired Immune Deficiency Syndrome (AIDS) caused by a Human Immunodeficiency Virus (HIV) the flow cytometry became irreplaceable. Traditionally, immunologists examine standard model of an estimation of immune dysfunction on the basis of classical markers of Т-cells (CD3, CD4, CD8) at the HIV-infection. But researchers pay less attention to other populations and subpopulations of lymphocytes, such as γδ-, αβ- and CD38+ Т-cells. The quantitative estimation of these parameters from a HIV and AIDS patients enables to see pathogenesis a HIV infection and the prediction of its development from another side.</p><p> </p

Topics: проточная цитометрия, СПИД, CD38, ВИЧ, TcR, γδ-T-клетки, αβ-T-клетки, Infectious and parasitic diseases, RC109-216
Publisher: Sankt-Peterburg : NIIÈM imeni Pastera
Year: 2011
OAI identifier: oai:doaj.org/article:2dd290dd4399477187747f83e8c10aae
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