Location of Repository

LISTERIA MONOCYTOGENES: SPREADING AND MECHANISMS OF IMMUNE RESPONSE

By I. F. Antoshina and M. V. Mezentseva

Abstract

<p><strong>Abstract.</strong> Gram-positive bacteria Listeria monocytogenes (LM) the causative agent of listeriosis is one of the pathogens entering to the human organism by food products. The listeriosis is one of the oldest experimental infection and LM is the classic object for study of cell immunity mechanisms. It was established that virulent bacteria L. monocytogenes induce infected immune cells to avoid own protective response. The authors conducted experiments to study changes in immune response indicators in mice in the different stages of infection (during 3–5 days) caused by L. monocytogenes EGDe (wt) strain and bacteria of isogeneic strains with mutations in genes controlled production of PAMPs (d28, i28). Analysis of published data and obtained results of this study allows to make a conclusion that immune response in listeriosis plays an important role and it depends on pathogen strain, bacteria doses and another condition of infection. Conducted study can be useful in case of choosing of treatment tactic of disease caused by Listeria monocytogenes, and, probable another diseases, caused by intracellular bacteria.</p

Topics: Listeria monocytogenes, листериоз, иммунитет, цитокины, интерлейкины, интерфероны, Infectious and parasitic diseases, RC109-216
Publisher: Sankt-Peterburg : NIIÈM imeni Pastera
Year: 2012
OAI identifier: oai:doaj.org/article:b4b809b3a2c3436f9b872d6051f441c5
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2313-7398 (external link)
  • https://doaj.org/toc/2220-7619 (external link)
  • http://iimmun.ru/iimm/article/... (external link)
  • https://doaj.org/article/b4b80... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.