Skip to main content
Article thumbnail
Location of Repository

IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS

By L. G. Tarasova and E. N. Strel’tsova

Abstract

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>In 46 patients with active pulmonary tuberculosis who were treated in 2014, the features of the immunological status by defining standard immunograms and serum levels of TNF</span><span>α</span><span>, IL-1</span><span>β</span><span>, IL-10, as well as autoantibodies to collagen I and III type have been studied. It was established that the hyperproduction of T lymphocytes mainly Th2 link (increased relative to the T</span><span>rel </span><span>content of 17.4% of the T</span><span>abs </span><span>— 30.4%, IL-1</span><span>β </span><span>— 32.6%, IL-10 — 43.5%) arises because of the decrease in the phagocytic activity of the cells (ratio of active phagocytes 1.98±1.07 at a rate of 2.5–2.9; percentage phagocytosis 56.35±13.89% at a rate of 65–95%). The increase in the content of B-lymphocytes (B</span><span>rel </span><span>— 84.8%, in the B</span><span>abs </span><span>— 43.5%) and circulating immune complexes, in some cases combined with decreased levels of immunoglobulins G, A, M, believe, intended to compensate the negative impact of </span><span>Mycobacterium tuberculosis </span><span>the body of the patient. The larger the specific process, the more intense the metabolism of connective tissue, stimulates the formation of type-specific autoantibodies involved in the elimination of connective tissue components. Detecting increased levels of autoantibodies to collagen type I — 50% and type III — 26.1%, probably due to the fact that in the initial stage of development of pulmonary tuberculosis «pulmonary collagen» is involved in the pathological process is less than I type. </span></p></div></div></div

Topics: туберкулез, TNFα, IL-1β, IL-10, коллаген I типа, коллаген III типа, аутоантитела, Infectious and parasitic diseases, RC109-216
Publisher: Sankt-Peterburg : NIIÈM imeni Pastera
Year: 2015
OAI identifier: oai:doaj.org/article:9dc4fb60eb5f46b9b626f82946cf9ae0
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2313-7398 (external link)
  • https://doaj.org/toc/2220-7619 (external link)
  • http://iimmun.ru/iimm/article/... (external link)
  • https://doaj.org/article/9dc4f... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.