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EFFECTS OF ATORVASTATIN IN PATIENTS WITH RHEUMATOID ARTHRITIS AND DYSLIPIDEMIA

By N. M. Nikitina and A. P. Rebrov

Abstract

<p><strong>Objective:</strong> to evaluate the basic and pleiotropic effects of atorvastatin in patients with rheumatoid arthritis (RA) and dyslipidemia (DLP).</p><p><br /><strong>Subjects and methods</strong>. The blood lipid profile was studied in 204 patients with RA. According to the found lipid disturbances, the patients<br />were randomized into 2 groups. A study group comprised 30 patients receiving generic atorvastatin 10 mg/day as part of combination therapy.<br />A comparison group included 20 RA patients matched for clinical characteristics and baseline lipid levels, who took no statins. Blood lipid<br />parameters and the markers of inflammation, vascular wall damage, and artery rigidity were examined over time.</p><p><br /><strong>Results.</strong> DLP was found in 58.3 % of the patients with RA. The use of atorvastatin in combination therapy resulted in not only a decrease in atherogenic cholesterol fractions, but also in a considerable reduction in the level of the markers of systemic inflammation and endothelial damage, and in disease activity. Six-month atorvastatin therapy showed a positive impact on the elastic properties of vessels in RA patients.</p><p><br /><strong>Conclusion.</strong> In RA patients with DLP, atorvastatin exerted a beneficial effect not only on the blood lipid profile, but also on the magnitude of inflammation and the elastic properties of vessels, and disease activity.</p

Topics: ревматоидный артрит, аторвастатин, дислипидемия, воспаление, жесткость артерий, Medicine, R
Publisher: ABV-press
Year: 2011
OAI identifier: oai:doaj.org/article:39e8d099c8b9401c87e14ac1cb370935
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