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A new view of the therapy of osteoarthrosis

By T A Raskina and Marina Vasilyevna Letaeva

Abstract

The insights into the pathogenesis of osteoarthrosis (OA) are being constantly expanded. A great role in the development of OA is assigned to immune disorders, particularly to proinflammatory cytokines (interleukin-1 — IL-1, tumor necrosis factor-α). Among the proinflammatory mediators, IL-1 is of the greatest value. Diacerein that is acetylated derivative of rein is used to inhibit the activity of IL-1 in OA. Nonsteroidal anti-inflammatory drugs, nimesulide in particular, reduce the activity of cytokines to some degree

Topics: остеоартроз, диацереин, нимесулид, Medicine, R
Publisher: IMA-PRESS LLC
Year: 2012
OAI identifier: oai:doaj.org/article:e7af560d844242afa348f7c954df192b
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