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A novel approach to treating osteoarthrosis as a chronic inflammatory disease

By Rimma Mikhailovna Balabanova

Abstract

A large role in the pathogenesis of osteoarthrosis (OA) is assigned to proinflammatory cytokines, such as interleukin 1 (IL1) and tumor necrosis factor-α, which activate catabolic processes in the cartilaginous tissue and subchondral bone. Diacerein is a medication that is able to block IL1 receptors, to lower the activity of metalloproteinases and nitric oxide, and thus to prevent joint inflammation and destruction in OA

Topics: остеоартроз, диацереин, Medicine, R
Publisher: IMA-PRESS LLC
Year: 2013
OAI identifier: oai:doaj.org/article:13aaeef7b8c0416c8bf8f42f82757fbf
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