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INSULIN-LIKE GROWTH FACTOR-1 AFTER ORTHOTOPIC LIVER TRANSPLANTATION IN CHILDREN WITH CONGENITAL AND HEREDITARY DISEASES OF HEPATOBILIARY SYSTEM

By O.P. Shevchenko, O.M. Tsirulnikova, A.V Bougrov, Y.E. Lourie, I.E. Tsirulnikova, D.S. Mnatsakanyan, O.E. Gichkun and S.V. Gautier

Abstract

<p><span>The research of total and free insulin-like growth factor-1 (IGF-1) in 53 children with with congenital and hereditary diseases of hepatobiliary system was performed before liver transplantation, a month and a year after liver transplantation. Data of our research work revealed reliable decrease of total and free IGF-1 serum concentrations in children with liver cirrhosis and controversy increase of PAPP-A, which regulates IGF-1 bioavailability. In a month after orthotopic liver transplantation the level of both fractions of IGF-1 restored. A year later concentrations of total and free IGF-1, and PAPP-A remained at normal rates. Increase of total and free IGF-1 after liver transplantation may contribute to restoration of endocrine regulation of growth, reparative and anabolic processes, and normal physical development of children. </span></p

Topics: инсулиноподобный фактор роста-1, цирроз печени, трансплантация печени., Surgery, RD1-811
Publisher: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
Year: 2012
OAI identifier: oai:doaj.org/article:71a0151be5e543d2b9720facc7164694
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