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By V. E. Syutkin, O. I. Andreytzeva, A. A. Salienko, A. O. Chugunov and A. V. Chzhao


<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><span>To compare clinical and virologic course of </span><span>de novo </span><span>and recurrent HBV infection 104 liver graft recipients with 6 months and more follow-up after cadaveric transplantation have been analyzed. Recurred HBV infection occurred in 7 (30.4%) out of 23 HBsAg-positive and </span><span>de novo </span><span>HBV infection – in 11 out of 81 (13.6%) HBsAg- negative recipients. HBeAg and IgM anti-HBc appeared in 8 recipients with </span><span>de novo </span><span>and in one case – with recurrent infection. Two recipients with </span><span>de novo </span><span>HBV developed acute hepatitis with jaundice and one – chronic hepatitis with graft cirrhosis. Only one recipient with recurrent HBV developed severe acute hepatitis HBV/ HDV, with anti-HBs seroconversion after 12 weeks of peginterferon alfa treatment. Nucleoside analogs (NA) were started in all 11 </span><span>de novo </span><span>HBV cases and in 5 cases of recurrent HBV infection. Treatment with NA effec- tively suppressed HBV DNA replication in both recurrent and </span><span>de novo </span><span>infections; HBsAg clearance occurred in 64% of </span><span>de novo </span><span>HBV and in 20% – of recurrent HBV cases. No secondary drug resistance occurred. </span><span>De novo </span><span>HBV infection is a self-limited disease in most cases, and preemptive NA treatment is the best treatment choice. Recurrent HBV infection is usually chronic, and pegylated interferon may be under consideration as well as NA. </span></p></div></div></div></div

Topics: трансплантация печени, пегилированный интерферон, инфекция HBV de novo, инфекция HBV возвратная, упреждающая терапия., Surgery, RD1-811
Publisher: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
Year: 2011
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