Skip to main content
Article thumbnail
Location of Repository

THERAPEUTIC ANGIOGENESIS BY GROWTH FACTORS AND BONE MARROW MONONUCLEAR CELLS ADMINISTRATION: BIOLOGICAL FOUNDATION AND CLINICAL PROSPECTS

By D. V. Bulgin and O. V. Andreeva

Abstract

<p>Angiogenesis is the process of new capillary formation by migration and proliferation of differentiated endothelial cells from pre-existing microvascular network. A number of angiogenic molecules and cell populations are involved in this complex of new vessel formation cascades resulting in the determination and organization of new tridimensional vascular network. The goal of therapeutic angiogenesis is to stimulate angiogenesis to improve perfusion, to deliver survival factors to sites of tissue repair, to mobilize regenerative stem cell populations, and<br />ultimately to restore form and function to the tissue. Growth factors and bone marrow as a source of bone marrow mononuclear cells represent a very interesting research fi eld for the realization of therapeutic angiogenesis in ischemic tissues. They provide a potential key component in the healing processes of ischemic injured tissues.</p

Topics: терапевтический ангиогенез, факторы роста, мононуклеарные клетки костного мозга, клеточная трансплантация, регенерация ишемических тканей, Surgery, RD1-811
Publisher: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
Year: 2015
OAI identifier: oai:doaj.org/article:b7cba34ab2914f1ba76b359e51e270e9
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2412-6160 (external link)
  • https://doaj.org/toc/1995-1191 (external link)
  • http://journal.transpl.ru/vtio... (external link)
  • https://doaj.org/article/b7cba... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.