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Synthesis, characterization and biological activities of some azo derivatives of aminothiadiazole derived from nicotinic and isonicotinic acids

By Ivan Hameed R. Tomi, Ali Hussein R. Al-Daraji, Raya Raad T. Al-Qaysi, Mohammed Mujbel Hasson and Khlood Hamed D. Al-Dulaimy


In this study we synthesized the new compounds containing bis-1,3,4-thiadiazole 3(A–D)n from many reaction steps (cyclization, diazotization and etherification respectively). The compounds have been characterized by melting point, FT-IR and 1H NMR data. All the synthesized compounds have been evaluated in vitro for their antimicrobial activities against several microbes like: Escherichia coli, Klebsiellia pneumonia, Pseudomonas aeruginosa, Serratia marscens and Staphylococcus aureus and show that some of these compounds have very good antibacterial activity

Topics: Antibacterial, Aminothiadiazole, 13,4-Thiadiazole, Azo compounds, Cyclization, Microbial activity, Chemistry, QD1-999
Publisher: Elsevier
Year: 2014
DOI identifier: 10.1016/j.arabjc.2010.12.003
OAI identifier: oai:doaj.org/article:2b021cf4dbca424da6f13ef189375f84
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