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In vitro studies of the antileishmanial activity of the newer 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues

By Mohamed Jawed Ahsan, Md Yousuf Ansari, Praveen Kumar, Monika Soni, Sabina Yasmin, Surender Singh Jadav and Ganesh Chandra Sahoo


A series of new 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues (8a-n) were synthesized in search of potential therapeutics for leishmaniasis. All the compounds were characterized by infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The compounds were further evaluated for in vitro antileishmanial activity against promastigotes of Leishmania donovani as per the standard protocol reported elsewhere. 2-(2,4-Dichlorophenoxy)-N′-{[4-(morpholin-4-yl)phenyl]methylidene}acetohydrazide (8k) showed the most promising antileishmanial activity with IC50 of 48.10 µM, free from cytotoxicity (>153.08 µM)

Topics: Acetohydrazide analogues, Antileishmanial activity, Leishmania donovani, Medicine (General), R5-920, Science (General), Q1-390
Publisher: Elsevier
Year: 2016
DOI identifier: 10.1016/j.bjbas.2016.05.002
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