Skip to main content
Article thumbnail
Location of Repository

In vitro studies of the antileishmanial activity of the newer 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues

By Mohamed Jawed Ahsan, Md Yousuf Ansari, Praveen Kumar, Monika Soni, Sabina Yasmin, Surender Singh Jadav and Ganesh Chandra Sahoo

Abstract

A series of new 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues (8a-n) were synthesized in search of potential therapeutics for leishmaniasis. All the compounds were characterized by infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The compounds were further evaluated for in vitro antileishmanial activity against promastigotes of Leishmania donovani as per the standard protocol reported elsewhere. 2-(2,4-Dichlorophenoxy)-N′-{[4-(morpholin-4-yl)phenyl]methylidene}acetohydrazide (8k) showed the most promising antileishmanial activity with IC50 of 48.10 µM, free from cytotoxicity (>153.08 µM)

Topics: Acetohydrazide analogues, Antileishmanial activity, Leishmania donovani, Medicine (General), R5-920, Science (General), Q1-390
Publisher: Elsevier
Year: 2016
DOI identifier: 10.1016/j.bjbas.2016.05.002
OAI identifier: oai:doaj.org/article:6c919e64dfb1459d9602b1e7ebe9639e
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2314-8535 (external link)
  • http://www.sciencedirect.com/s... (external link)
  • https://doaj.org/article/6c919... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.