Background: Cardiovascular diseases have become a leading cause of morbidity and mortality in adult population of Indian sub-continent. Aim of the study was to compare the serum lipid patterns in patients with proven premature CAD and its first degree relative in a tertiary care hospital of South-eastern region of Rajasthan, India. Methods: 200 patients with the primary diagnosis of premature coronary artery disease were enrolled. These patients and their 643 first-degree relatives, who were in the coronary age group 25 years and above also enrolled for the purpose of the study. Fasting lipid profile was estimated. Results: 36.5% of the males and 4.5% female patients were having abnormal cholesterol levels. 30.5 % of male of premature CAD were having high LDL levels as compared to only 2.5% of the females (p<0.05). High LDL level was 33.0%. Low HDL cholesterol in CAD patients were in 36.0% of males and 4.0% of the females (p<0.05). High Triglyceride levels (53.5%) in the CAD patients were 46.5% males and 6.5% females. (p<0.05). Irrespective of sex, majority of relatives (70.7%) were having desirable total cholesterol levels while high total cholesterol was there in only 10.1% of the relatives.21.4% of male relatives of CAD patients were having abnormal LDL levels as compared to 7.4% of the females (p<0.05). Conclusions: For hyper cholestolaemia, routine screening of all adults older than 20 years is recommended. Therapeutic targets for lipid levels are recommended depending on overall risk for patients with CAD or a CAD risk equivalent such as diabetes or peripheral arterial disease. [Int J Res Med Sci 2016; 4(8.000): 3354-3359
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