Background: The present study was aimed at studying the effect of practicing yoga in patients with type 2 DM for 4 months. The practice of yoga in these patients resulted in a decrease in body weight, total cholesterol, triglycerides and LDL cholesterol and an increase in HDL. Yoga based programs are a low-cost intervention strategy to improve physical and psychological well-being. Rhythmic extension and bending in yoga provides stimulation to organs and glands without straining the muscles. Yoga could be also useful in patient suffering from insulin resistance syndrome. Methods: 50 patients with known type 2 diabetes mellitus and dyslipidemia were selected for the study. Known diabetic patients on treatment with sulphonylurea were also included in this study. 50 patients with type 2 DM attending the diabetic clinic were randomized into control group and study group of 25 patients each. The study group was on oral hypoglycemic drugs, lifestyle modification and yoga for a period of 4 months. The control group was prescribed oral hypoglycemic drugs only and did not perform yogic exercises during this period. Results: 4 months of study has shown that patient enrolled in study group had mild decrease in BMI, and body weight which was not statistically significant but there was a significant reduction in total cholesterol, triglycerides and LDL cholesterol, apart from it, there was a non-significant elevation in HDL. Control group showed a significant increase in body weight. It was also noted that there was non-significant increase in total cholesterol, triglycerides and a decrease in HDL. The bodyweight increase could be attributed to drugs like Sulphonylurea also. Conclusions: Yoga has been tried for its benefit not only in India bur also in developed countries. In view of the benefits of yoga therapy in short-term studies and long-term studies, more awareness and emphasis should be given for it. Patient should be explained clearly about the beneficial effects of yoga. Yoga can help in improved lipid profiles, lower BMI, and lowers glycemic levels which can have a long term beneficial effect on Micro and macro-vascular complications in diabetes. [Int J Res Med Sci 2016; 4(8.000): 3504-3508
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