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PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation

By Mabeta Peace

Abstract

PF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. The aim of this study was to evaluate the effects of PF573,228 on the cells derived from mouse vascular tumors, namely, endothelioma cells

Topics: PF573,228, focal adhesion kinase, endothelioma, apoptosis, angiogenesis, Pharmaceutical industry, HD9665-9675
Publisher: De Gruyter Open
Year: 2016
DOI identifier: 10.1515/acph-2016-0031
OAI identifier: oai:doaj.org/article:e17d04c4d5224207a0cf4135975e6d77
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