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Serum levels of inhibin B in adolescents after varicocelelectomy: A long term follow up

By Molinaro Francesco, Cerchia Elisa, Garzi Alfredo, Severi Francesco Maria, Angotti Rossella, Petraglia Felice and Messina Mario


To study the impact on adult’s fertility of serum inhibin B levels in adolescent patients with idiopathic varicocele after minimally invasive surgical correction and to compare fluctuation of pituitary-testis hormonal values and testicular volumes. Materials and Methods: A case-control study was carried out on a group adolescent patients (n=60) affected by idiopathic left varicocele (group V) and compared with control adolescents (n=40) in the Paediatric Surgery Section of Siena (from June 1993 till September 2013). Inhibin B levels and testicular volume before (T0) and after at 6 and 12 months from surgery (T1 and T2) were evaluated. Results: A positive correlation between testicular growth at T1 and T2 (P<0.001) was found. Linear regression analysis showed a positive correlation between inhibin B levels and testicular volume (expressed as the sum of the right and left values) (P<0.0001). Conclusions: Inhibin B levels are a valid marker for studying the effects of varicocele on the testicular function and confirm the necessity of early surgical correction for preventing the trophic testicular damage and male infertility

Topics: Lung Sparing Surgery, intralobar pulmonary sequestration, pediatric thoracic surgery, Medicine, R
Publisher: De Gruyter Open
Year: 2016
DOI identifier: 10.1515/med-2016-0039
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