Background: An increasing interest in intravenous anesthetic agent has resulted from the availability of more effective intravenous agents. Objectives: Comparison of intravenous Ketamine with combination of intravenous Propofol and Fentanyl in ASA Gr. 1 patients of middle age in minor surgical procedures, To compare the haemodynamic fluctuation of intravenous Ketamine with intravenous propofol and ndash; fentanyl combination in short surgical procedure and to compare recovery and side-effective in postoperative period of intravenous Ketamine with intravenous propofol- Fentanyl combination in short surgical procedures. Methodology: This observational study includes 20 patients of ASA Grade I of either sex, especially those who were coming for minor surgery. Patients divided in group A: Patients were preoxygenated with 100% oxygen. Induction was done with injection Ketamine 2 mg/kg intravenous. O2 was given throughout surgery and group B: Patients were preoxygenated with 100% oxygen. Induction was done with inj. Fentanyl citrate I mg/kg over 1 minute followed after 3 minute by propofol 2.5 mg/kg O2 was given throughout surgery. Results: Highest patients belong to 21-30 years age group. Female were higher in both the group that male. Most of (18) patients belongs to 51 to 40 kg group. Falling in blood pressure and pulse was more in Group B than Group A patients. Post-operative side effects more seen Group A than Group B patients. Conclusion: Inspite of more side effects and more change in hemodynamics parameters in Propofol-fentanyl group than Ketamine group, Both Ketamine and Propofol and ndash;fentanyl combinations produce rapid, pleasant and safe anesthesia with only a few untoward side effects and only minor hemodynamic effects. [Natl J Med Res 2016; 6(1.000): 92-94
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