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Increased voltage-dependent K+ channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness

By Joanna Bielanska, Javier Hernández-Losa, Terersa Moline, Rosa Somoza, Santiago Ramón y Cajal Agüeras, Enric Condom i Mundó, Joan C. Ferreres and Antonio Felipe Campo

Abstract

Voltage-dependent K+ channels (Kv) are involved in the proliferation and differentiation of mammalian cells, since Kv antagonists impair cell cycle progression. Although myofibers are terminally differentiated, some myoblasts may re-enter the cell cycle and proliferate. Since Kv1.3 and Kv1.5 expression is remodeled during tumorigenesis and is involved in smooth muscle proliferation, the purpose of this study was to analyze the expression of Kv1.3 and Kv1.5 in smooth muscle neoplasms. In the present study, we examined human samples of smooth muscle tumors together with healthy speci­mens. Thus, leiomyoma (LM) and leiomyosarcoma (LMS) tumors were analyzed. Results showed that Kv1.3 was poorly expressed in the healthy muscle and indolent LM specimens, whereas aggressive LMS showed high levels of Kv1.3 expression. Kv1.5 staining was correlated with malignancy. The findings show a remodeling of Kv1.3 and Kv1.5 in human smooth muscle sarcoma. A correlation of Kv1.3 and Kv1.5 expression with tumor aggressiveness was observed. Thus, our results indicate Kv1.5 and Kv1.3 as potential tumorigenic targets for aggressive human LMS

Topics: Leucòcits, Càncer, Macròfags, Fisiologia cel·lular, Canals de potassi, Leucocytes, Cancer, Macrophages, Cell physiology, Potassium channels
Publisher: Spandidos Publications
Year: 2014
DOI identifier: 10.3892/ol.2012.718
OAI identifier: oai:diposit.ub.edu:2445/58597
Journal:

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