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Using networks to study reduced penetrance of blister genes in Caenorhabditis elegans

By Molly Quay-de la Vallee

Abstract

Networks are a useful tool in systems biology that provides a visual representation for\ud interactions between genes. By creating a network of interactions between blister genes with a program GeneMANIA, this technique was used to study reduced penetrance in Caenorhabditis\ud elegans. By testing the interactions predicted in the network from GeneMANIA, a couple\ud interactions were found. It was found that dpy-11 and dpy-9 suppressed the penetrance of blisters\ud in 4 different blister strains and, when grown on dpy-11 RNAi, bli-5 (e518) mutants developed\ud an interesting phenotype in which the worms were very dumpy and their cuticle was completely\ud separated from the body. Using a network of gene interactions can serve as a starting point in\ud testing gene interactions that are significant in the penetrance of a particular trait. The testing of a genetic network of blister interactions has identified a couple interactions that affect the penetrance and life of the worm

Year: 2014
OAI identifier: oai:triceratops.brynmawr.edu:10066/14724
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