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Neurodevelopmental outcome at seven years in term, acidotic newborns

By M Diviney, R Pinnamaneni, JFA Murphy, B Lynch, H Rushe, C Madigan, M Geary and A Foran


The objective was to follow up a cohort of acidotic full-term infants with or without hypoxic ischemic encephalopathy\ud (HIE) and determine if at 7 years they displayed any neurodevelopmental delays. Children (n=44) were divided according\ud to those with mild (n=25) or severe (n=19) acidosis and were then further subdivided into those with or without HIE.\ud Participants were assessed using the Wechsler Intelligence Scale for Children (WISC-IVUK) and Achenbach Child\ud Behaviour Checklist (CBCL). No differences in WISC-IVUK scores in children without HIE irrespective of the cord pH\ud values were found. Children with HIE grade I scored significantly higher in perceptual reasoning than those with grade\ud III (p<0.01). CBCL scores revealed no differences between groups. Findings suggest evidence of impairment at\ud school-age that correlates with the degree of encephalopathy. Acidosis without the presence of clinical encephalopathy\ud was associated with normal outcome

Publisher: Irish Medical Journal
Year: 2015
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