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Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity

By Yichuan Wang, Yongjun Sui, Shingo Kato, Alison E. Hogg, Jason C. Steel, John C. Morris and Jay A. Berzofsky


The structured lymphoid tissues are considered the only inductive sites where primary T-cell immune responses occur. The naïve T cells in structured lymphoid tissues, once being primed by antigen-bearing dendritic cells, differentiate into memory T cells and traffic back to the mucosal sites through the bloodstream. Contrary to this belief, here we show that the vaginal type-II mucosa itself, despite the lack of structured lymphoid tissues, can act as an inductive site during primary CD8 + T-cell immune responses. We provide evidence that the vaginal mucosa supports both the local immune priming of naïve CD8 + T cells and the local expansion of antigen-specific CD8 + T cells, thereby demonstrating a different paradigm for primary mucosal T-cell immune induction

Topics: 1300 Biochemistry, Genetics and Molecular Biology, 1600 Chemistry, 3100 Physics and Astronomy
Publisher: Nature Publishing Group
Year: 2015
DOI identifier: 10.1038/ncomms7100
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