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Clostridium difficile and its toxins

By Saleem Hafiz

Abstract

An investigation of Clostridium difficile has shown :\ud \ud 1. that the organism is resistant to cresols and phenolq\ud and may be grown from material grossly contaminated with\ud other organisms by culture in media containing these\ud substances; strains isolated before this method was\ud evised are also resistant to cresols and phenol;\ud \ud 2. that the organism divides into four daughter cells;\ud \ud 3. that each strain examined has a different strain specific\ud agglutinogen, and that the strains are otherwise\ud antigenically complex;\ud \ud 4. that the sugar reactions are fairly consistent\ud \ud 5. that gelatin is liquefied by all available strains in\ud three weeks; and that apart from this there is no\ud proteolytic activity\ud \ud 6. that the hyaluronidase produced by all strains is\ud antigenically uniform? and so is the lethal toxin;\ud \ud 7. and that the 'haemolysin' is almost certainly complex

Publisher: Faculty of Biological Sciences (Leeds)
Year: 1974
OAI identifier: oai:etheses.whiterose.ac.uk:972

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