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Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels

By W. Widagdo, V.S. (Stalin) Raj, D. (Debby) Schipper, K. (Kimberley) Kolijn, G.J.H.L. (Geert) Leenders, B.J. (Berend Jan) Bosch, A. (Albert) Bensaid, J. (Joaquim) Segalés, W. (Wolfgang) Baumgärtner, A.D.M.E. (Albert) Osterhaus, M.P.G. (Marion) Koopmans D.V.M., J.M.A. (Judith) van den Brand and B.L. (Bart) Haagmans


Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission

Year: 2016
DOI identifier: 10.1128/JVI.02994-15
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