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Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

By M. Mohty, F. Malard, M. Abecassis, E. Aerts, AS. Alaskar, M. Aljurf, M. Arat, P. Bader, Frédéric Baron, A. Bazarbachi, D. Blaise, F. Ciceri, S. Corbacioglu, J-H. Dalle, RF. Duarte, T. Fukuda, A. Huynh, T. Masszi, M. Michallet, A. Nagler, M. NiChonghaile, T. Pagluica, C. Peters, FB. Petersen, PG. Richardson, T. Ruutu, BN. Savani, E. Wallhult, I. Yakoub-Agha and E. Carreras

Abstract

Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children.Peer reviewe

Topics: Human health sciences :: Hematology, Sciences de la santé humaine :: Hématologie
Year: 2015
OAI identifier: oai:orbi.ulg.ac.be:2268/183675

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