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Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies

By RE Banks, AJ Gearing, IK Hemingway, DR Norfolk, TJ Perren and PJ Selby

Abstract

Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and extends previous studies reporting measurement of circulating ICAM-1. Soluble ICAM-1 and VCAM-1 levels were significantly higher in all the patient groups compared with the controls whereas soluble E-selectin was significantly higher in the ovarian, breast and GI cancer groups and lower in the myeloma group. The significance of these results together with the possible sources and stimuli for release of these adhesion molecules are discussed

Publisher: 'Springer Science and Business Media LLC'
Year: 1993
DOI identifier: 10.1038/bjc.1993.298
OAI identifier: oai:eprints.whiterose.ac.uk:100575

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