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Alzheimer: nasal transplantation of microglia

By Claire Fabian, Yahaira Naaldijk and Alexandra Stolzing

Abstract

This paper was accepted for publication in the journal Experimental Gerontology and the definitive published version is available at http://dx.doi.org/10.1016/j.exger.2015.01.010Alzheimer’s disease (AD) is an age-related neurodegenerative disease associated with the formation of amyloid plaques, [tau] aggregation and oxidative/inflammatory damage. Microglia play an important role in the early phase of the disease and are known to be involved in AD progression. Senescent microglia accumulate in AD causing inflammation, neuronal damage and increasing the A[beta] load. Microglia could be an attractive target for mesenchymal cell therapies (MSC)

Topics: Alzheimer's disease, Microglia, Mesenchymal stem cells
Publisher: © Elsevier
Year: 2015
DOI identifier: 10.1016/j.exger.2015.01.010
OAI identifier: oai:dspace.lboro.ac.uk:2134/20648
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