An antiviral substance from penicillium cyaneo-fulvum (in vivo studies)

Abstract

A strain of Penicillium cyaneo-fulvum, isolated in the Department of Bacteriology and Immunology, McGill University by Dr. G. D. Denton in 1947, * was found to produce a toxin neutralizing substance, Noxiversin (Diena, 1954, 1956; Tanner, 1956, 1957; Murray et al., 1958), as well as a separate and distinct antiviral substance (Cooke, 1958, 1960; Cooke and Stevenson, 1965 a, b). The antiviral agent, in both its crude and partially purified forms, was found to reduce the infectivity of influenza virus in embryonated eggs, modified Maitland cultures, monkey kidney cell cultures, and mice (Diena, 1956; Cooke, 1958, 1960; Syeklocha, 1962, 1964; Cooke and Stevenson, 1965b; David-West, 1966)