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Development of chitosan/heparin nanoparticle-encapsulated cytolethal distending toxin for gastric cancer therapy

By Cheng-Kuo Lai, Yu-Luen Lu, Jer-Tsong Hsieh, Shih-Chang Tsai, Chun-Lung Feng, Yuh-Shyan Tsai, Pei-Ching Tsai, Hong-Lin Su, Yu-Hsin Lin and Chih-Ho Lai


The aim of this work was to develop pH-responsive nanoparticles encapsulating CdtB and to demonstrate that these particles represent a potential therapeutic agent for gastric cancer

Topics: apoptosis, cell cycle, chitosan, cytolethal distending toxin, heparin, nanoparticle, Antineoplastic Agents, Apoptosis, Bacterial Toxins, Cell Line, Tumor, Cells, Cultured, Chitosan, Delayed-Action Preparations, Heparin, Humans, Hydrogen-Ion Concentration, Immunosuppressive Agents, Nanoparticles, Stomach, Stomach Neoplasms
Year: 2015
DOI identifier: 10.2217/nnm.13.54
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