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Transcription Repressor Slug Promotes Carcinoma Invasion and Predicts Outcome of Patients with Lung Adenocarcinoma

By J.-Y. Shih


In a previous genome-wide gene expression profiling analysis using an invasion cancer cell lines model, we have identified Slug as selectively overexpressed in the highly invasive cancer cells. Here, we investigated the clinical significance of Slug in lung adenocarcinoma and the role of Slug in the process of cancer cell invasion and metastasis

Topics: Adenocarcinoma, Aged, Animals, Blotting, Northern, Cadherins, Cell Line, Tumor, Cell Movement, Cell Proliferation, Female, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, Male, Matrix Metalloproteinase 2, Mice, Mice, SCID, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Neoplasm Transplantation, Neoplasms, Experimental, Neovascularization, Pathologic, Prognosis, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Survival Analysis, Transcription Factors, Transfection, Transplantation, Heterologous, Treatment Outcome
Year: 2015
DOI identifier: 10.1158/1078-0432.CCR-05-0687
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