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Genotoxic Klebsiella pneumoniae in Taiwan

By Yi-Chyi Lai, Ann-Chi Lin, Ming-Ko Chiang, Yu-Han Dai, Chih-Chieh Hsu, Min-Chi Lu, Chun-Yi Liau and Ying-Tsong Chen

Abstract

Colibactin is a nonribosomal peptide-polyketide synthesized by multi-enzyme complexes encoded by the pks gene cluster. Colibactin-producing Escherichia coli have been demonstrated to induce host DNA damage and promote colorectal cancer (CRC) development. In Taiwan, the occurrence of pyogenic liver abscess (PLA) has been suggested to correlate with an increasing risk of CRC, and Klebsiella pneumoniae is the predominant PLA pathogen in Taiwan

Topics: Animals, Cell Line, DNA Damage, Gene Deletion, Genes, Bacterial, Humans, Klebsiella Infections, Klebsiella pneumoniae, Liver, Liver Abscess, Pyogenic, Mice, Inbred BALB C, Mutagens, Peptides, Polyketides, Taiwan, Multigene Family
Year: 2015
DOI identifier: 10.1371/journal.pone.0096292
OAI identifier: oai:ir.lib.nchu.edu.tw:11455/86403
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