This study developed a TiO2/PLGA [poly(lactic-co-glycolic acid)] composite biomaterial, which possesses antibacterial properties but is biocompatible, for artificial dressing applications. A sol-gel method was used for the preparation of the nano TiO2 powder with anatase phase. Several concentration ratios of TiO2 versus PLGA were analyzed to optimize the disinfection efficiency of the composite biomaterial. The antibacterial activity of the fabricated TiO2/PLGA composite was measured against Staphylococcus aureus and Escherichia coli. To evaluate the feasibility of the biomaterial on wound healing in vitro, human keratinocytes (HaCaTs), fibroblasts (L929s), and bovine carotid artery endothelial cells (BECs) were seeded on the TiO2/PLGA composite biofilms. To investigate the histological effect of the biocompatible biofilm in vivo, a rat subcutaneous implantation was performed. Our results show that TiO2/PLGA composite biofilms containing 10% TiO2 nanoparticles have an effective antibacterial property, a good survival rate on HaCaTs and L929s, and relative safe stability in tissue implantation
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