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The Interplay of Reovirus with Autophagy

By Hung-Chuan Chiu, Sarah Richart, Fong-Yuan Lin, Wei-Li Hsu and Hung-Jen Liu


Autophagy participates in multiple fundamental physiological processes, including survival, differentiation, development, and cellular homeostasis. It eliminates cytoplasmic protein aggregates and damaged organelles by triggering a series of events: sequestering the protein substrates into double-membrane vesicles, fusing the vesicles with lysosomes, and then degrading the autophagic contents. This degradation pathway is also involved in various disorders, for instance, cancers and infectious diseases. This paper provides an overview of modulation of autophagy in the course of reovirus infection and also the interplay of autophagy and reovirus

Topics: Autophagy, Humans, Lysosomes, Protein Aggregation, Pathological, Reoviridae, Reoviridae Infections
Year: 2015
DOI identifier: 10.1155/2014
OAI identifier:

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