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In vitro anti-inflammatory effect of apigenin in the Helicobacter pylori-infected gastric adenocarcinoma cells

By Yuan-Chuen Wang and Kai-Ming Huang


AP-1, activator protein 1; CagA, cytotoxin associated antigen; COX-2, cyclooxygenase-2; ERK1/2, extracellular signal regulated kinase 1/2; EtBr, ethidium bromide; H2DCF-DA, dihydrodichlorofluorescein diacetate; HE, dihydroethidium; ICAM-1, intercellular adhesion molecule-1; IKKα/β, IκB kinase α/β; IL-8, interleukin-8; MUC-2, mucin-2; iNOS, inducible nitric oxide synthase; JNK, C-terminal Jun-kinase; LPS, lipopolysaccharide; 5-LOH, 5-lipooxygenase; MAPK, mitogen-activated protein kinase; NF-κB, nuclear factor kappa B; NIK, NF-κB-inducing kinase; Nox, NADPH oxidase; PGE2, prostaglandin E2; ROS, reactive oxygen species; TRL4, toll-like receptor 4; T4SS, type IV secrete system; VacA, vacuolating cytotoxi

Topics: Apigenin, Oxidative burst, Helicobacter pylori, Inflammation, Gastric cancer
Year: 2014
DOI identifier: 10.1016/j.fct.2012.12.018
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