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Synthesis of Hydroxylated Analogues of α-Galactosyl Ceramide (KRN7000)with Varying Stereochemistry

By Ratnnadeep C. Sawant, Jung-Tung Hung, Huei-Lin Chuang, Huan-Shuan Lin, Wan-Shin Chen, Alice L. Yu and Shun-Yuan Luo


The synthesis of analogues of α-galactosyl ceramide (KRN7000) with an additional hydroxy group in the phytosphingosine chains and with varying stereochemistry is described. Careful selection of glucose, galactose, mannose, and talose hexopyranoses allowed us to control the stereochemistry of some of the hydroxy groups in the sphingosine chain to give some interesting hydroxylated KRN7000 analogues

Topics: Carbohydrates, Glycolipids, Sphingolipids, Cerebrosides, Structure–activity relationships
Year: 2014
DOI identifier: 10.1002/ejoc.201301111
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