Preparation and Biomedical Applications of Magnetic Nanoparticle-based High-performance Magnetic Resonance Imaging Contrast Agents


磁共振成像造影剂可以改变组织的弛豫时间,从而改变组织的信号强度,有力地提高了组织的磁共振影像对比度,使得诊断更准确。因此,发展新型高性能磁共振成像造影剂具有重要的现实意义。本论文围绕高性能磁共振成像造影剂这一重大需求,设计合成了多种磁性无机纳米材料,并对其磁共振造影性能及生物应用潜能进行系统研究。 首先,基于高磁性的纳米材料往往可以产生更强的T2造影效果的思路,本论文合成了具高饱和磁化强度和优秀抗氧化性能的Fe5C2纳米颗粒,并对其磁共振造影性能进行研究。结果表明,Fe5C2纳米颗粒可以高效地缩短水质子的T2弛豫时间,是一种潜在的高性能T2磁共振造影剂。 其次,为了更好地理解磁性纳米颗粒中...Magnetic resonance imaging (MRI) contrast agents with the ability to shorten relaxation time of water protons can greatly improve the accuracy and specificity of MRI. Therefore, the search for MRI contrast agents with high efficiency is desirable and of great importance. In this thesis, three kinds of magnetic nanomaterials are exploited to serve as high-performance contrast agents for efficient M...学位:理学博士院系专业:化学化工学院_化学生物学学号:2052011015368

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oaioai:dspace.xmu.edu.cn:2288/81997Last time updated on 6/16/2016View original full text link

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