Skip to main content
Article thumbnail
Location of Repository

The effect of betahistine on gastric acid secretion and mucosal blood flow in conscious dogs

By B. P. Curwain, Pamela Holton and Jan Spencer


In 3 conscious dogs, betahistine (2-(2'-methyl aminoethyl pyridine)) (80 or 160μg kg-1 min-1) increased acid secretion from Heidenhain pouches to 8·8% and 17·6% respectively of the maximal response to histamine. Betahistine also increased mucosal blood flow (radioactive aniline clearance). The ratio of mucosal blood flow to secretion was greater for betahistine than for histamine but the difference between betahistine and histamine was significant in only one of the dogs

Topics: Short Communications
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.