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Nicotine washout rates from isolated rat ganglia in relation to recovery from nicotine depolarization

By D. A. Brown and C. N. Scholfield

Abstract

1. Isolated rat superior cervical ganglia recovered more slowly from the depolarizing action of nicotine than from that of carbachol or acetylcholine. This was due to sustained high nicotine concentrations in the vicinity of the receptors, since recovery was hastened by adding hexamethonium to the washout fluid

Topics: Autopharmacology
OAI identifier: oai:pubmedcentral.nih.gov:1666184
Provided by: PubMed Central
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