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A metabolic interaction in vivo between cannabidiol and Δ1-tetrahydrocannabinol

By G. Jones and R. G. Pertwee

Abstract

The effect of pretreatment with cannabidiol (CBD; 50 mg/kg i.p.) on the distribution of radioactivity in chromatograms of ethyl acetate extracts of the brains of mice injected with tritiated Δ1-tetrahydrocannabinol (3H-Δ1-THC; 1·0 mg/kg i.v.) was determined. The pretreatment with CBD produced significant increases in the levels of radioactivity in the brain assigned to Δ1-THC and its centrally active metabolite 7-hydroxy-Δ1-THC: the changes produced were respectively 1·4 and 2·0 fold

Topics: Short Communications
OAI identifier: oai:pubmedcentral.nih.gov:1666148
Provided by: PubMed Central
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