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TETRANUCLEOTIDE MICROSATELLITES ON THE MAP OF CHROMOSOME 13. THE ANALYSIS OF DISTRIBUTION AND APPLICATION TO THE MARKER'S CREATION

By Ganka Maneva Ivanova

Abstract

The object of investigation: tetranucleotide repeatitions on the chromosome of 13 of the man. The purpose of the work: the search for the new loci of the tetranucleotide microsatellites on the chromosome 13 and the formation of the new genetic markers on its base. The screening of the ordered clonotheca of chromosome 13 for the content of the consequences of three- and tetranucleotide repeatitions has been performed, and its distribution on the chromosome has been determined. 40 GATG- and GACT-positive cosmides have been localized with the FISH method on the metaphase chromosomes 16 cosmides have been recloned and partially sequenced have been the obtained reclones; 6 markers have been formed; the analysis of the association of the polymorph marker D13S699 (13q14) with shizophrenia has been given (is applied to solving the questions about the controversial paternity). The obtained data can be used in mapping of chromosome 13, in the genome dactiloscopy for identification of a person and in the associative analysis of the definite hereditary diseasesAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Topics: 06v - null, BIOLOGY
Year: 1996
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Provided by: OpenGrey Repository
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