INFLUENCE OF SOME IMIDAZOLE AND PYRIMIDINE DERIVATIVES ON EXPERIMENTAL ATHEROSCLEROSIS AMONG RABBITS AND CHOLESTERIN METABOLISM IN CULTIVATES HEPATOCYTES AND MACROPHAGES

Abstract

The work covers the experimental atherosclerosis and cholesterin metabolism in the cultivated hepatocytes and macrophages. It has been shown firstly that the 2-imidazolilpropane-2-sulphonic acid has exercised the antisclerotic effect among rabbits with experimental atherosclerosis influencing selectively on the cholesterin metabolism in macrophages. Both the hypolipemia effect of the xymedone and the expressed antisclerotic action on the vascular wall level have been revealed. The results showing the perspectivity of further studying imidazolsulphonic acid derivative for a purpose of making new preparations of the antiatherogenic action have been obtained. The information ability of using complex approach in the search of the new antiatherogenic compounds has been shown. Application field: medical biochemistry and pharmacologyAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio