The purpose of the work: to examine the variations of the degree of the blood serum glycoproteins glycosilating at the different physiological and pathological states and to evaluate the functional role of the glycan chains of these proteins. It has been established, that the degree of glycosilating of the sum glycoproteins and transferrine of the premature children and children with hypotrophy is being increased. The law variation of the structure of the blood orosomucoid glycan chains has been proved. It has been established, that growth-stimulating and antioxidant activity of transferrine in vitro depends on the degree of the its sialating. The presentation about the relative independence of regulating of metabolism of the glycan and polypeptide chains of glycoproteins has been formulated. Developed and introduced in operation of the Institute has been electrophoretic method of determination of the content and degree of glycosilating of the blood serum transferrine. The obtained data can be used for the justification of selection of the additional prognostic tests at the evaluation of heaviness of hypotrophy and prematurely born children.Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio
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