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CREATION AND CHARACTERISTICS OF MONOCLONAL ANTIBODIES TO K-ANTIGEN OF SALMONELLA

By Nataliya Vyacheslavovna Kovalchuk

Abstract

The panel of the monoclonal antibodies (MCA) to the K-antigens of the Salmonella has been obtained. By means of them the presence of the specific active generally generic determinants K-Ag and absence of the expressed decussation with other species of the enterobacteria have been shown, the relationship of the K-antigens has been shown also by means of the biochemical investigation in the protein part. The presence of the minor determinants K-Ag has been shown firstly. The generally generic antigenic determinants K-Ag has been characterized by means of the epitopic analysis, the difference of the connecting epitops of K-Ag from O-antigens of the Salmonella has been proved. On base of MCA with use of the immuno-fermental analysis the new diagnostic test-system for revealing excitators of the salmonellosis in the foods has been developed for a purpose of the prophilaxis at the acute intestinal diseases. The test-system doesn's have analogs and is used for quality control of the foods in the Moscow State UniversityAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Topics: 06V - Genetics, cytology, molecular biology, 06B - Bioengineering, biomedical engineering, biotechnology, biochemical engineering, BIOLOGY, BIOTECHNOLOGY, FOOD INDUSTRY
Year: 1996
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Provided by: OpenGrey Repository
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