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Screning and study of preparations - inhibitors of the man's immunodeficit virus (midv)

By Plyasunova Olga Alexandrovna

Abstract

The object of investigation: anti-MIDV preparations. The perpose of the work: searching for the anti-midv active preparations and studying its anti-MIDV action. The new inhibitors of the MIDV reproduction have been revealed: nyglizin, amides and glycopeptides of beta -glycirrizine acid, encyclan, meaning PM-20 and anti-meaning MP-20 oligonucleotides, its hydrophobic derivatives. The quantitative characteristics of the MIDV inhibiting for the number of preparations have been determined. It has been established that the glycyram, encyclan and aurine-carbonic acid are not antagonists of azidothymidine. The system for screening and comparative evaluation of the anti-MIDV preparations efficiency has been developed. The anti-MIDV activity of preparations of beta -glycirrizine acid, complex isobornyl ethers, anti-meaning oligonucleotides has been studied. The new inhibitors of the MIDV reproduction which can be used at creating of the MIDV infection treatment means have been revealed among them. The experimental batches of nyglizin habe been made in the Experimental plant at thee Institute of organic chemistry of the BSC of the Urals Enterprise of the Russian Academy of Sciences for the performance of the clinic tests on the MIDV-infected patientsAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Topics: 06O - Pharmacology, pharmacy, pharmaceutical chemistry, BIOLOGY,CHEMICAL TECHNOLOGY. CHEMICAL INDUSTRY
Year: 1992
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Provided by: OpenGrey Repository
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