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OKT4+ T cell deficiency and an association of immunoglobulin deficiency in systemic lupus erythematosus.

By S Raziuddin and B H Danial

Abstract

A patient with systemic lupus erythematosus and selective serum IgA and IgM deficiency also had a deficiency of OKT4+, OKT4A+, OKT4B+, and OKT4E+ T cells in circulating blood. This deficiency of helper/inducer T cell subsets in blood was associated with impaired T cell responses to phytohaemagglutinin in vitro, and an impaired ability to produce IgA and IgM by the patient's B cells. The patient's OKT4+ (CD4+) T cell deficient population suppressed IgM synthesis by normal B and T cells

Topics: Research Article
OAI identifier: oai:pubmedcentral.nih.gov:1541558
Provided by: PubMed Central
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