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Hyper-responsiveness in NZB mice to the experimental induction of anti-red cell autoantibody.

By A Cooke and J H Playfair

Abstract

Strain differences in ease of induction of autoantibody production were observed when mice were injected with rat RBC. Responsiveness was not linked to the H-2 locus. NZB and (NZB X BALB/c)F1 mice were hyper-responsive both in terms of the induction of autoantibody and in the production of agglutinating antibody to rat RBC. C57BL/c and (C57BL X BALB/c)F1 were poor responders. Injection of the rat RBC in FCA converted a poor responder into a good responder. Adult thymectomy and ALS treatment did not significantly enhance autoantibody production

Topics: Research Article
OAI identifier: oai:pubmedcentral.nih.gov:1540947
Provided by: PubMed Central
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